Cancer Antigen 125 (CA125)

Description

CaA-125 also known as a mocin 16
or MUC16 is a protein that in humans is encoded by MUC16 gene. C16 is a member
of the mucin family glycoproteins. CA-125 is the most frequently used biomarker
for ovarian cancer detection.

Product Specifications

Source

Human

Form

Liquid

Buffer

PBS, 20%
Sucrose, 0.1% Sodum Azide, pH 7.4

Concentration

≥ 50,000
IU/mL, assayd on Roche Centaur

Purity

Immunopure
and Purified

Cross
Reactivity

Partially
Purified: CEA, CA 15-3, CA 19-9< 15% Purified: ≥ 70% SDS-Page Immunopure: CEA, CA 15-3, CA 19-9<1%

Storage

2-8°C for
short term, -20°C for long-term storage

Molecular
Weight

Ranging from
200 to 2000kDa

Appearance

Colorless

Associated
Products

Cancer
Antigen 125 (CA 125): Partially Purified, Purified, and Immunopure

 

Around 90% of women with advanced
ovarian cancer have elevated levels of CA-125 in their blood scrum, making
CA-125 a useful tool for detecting ovarian cancer after the onset of symptoms.
CA-125 has limited specificity for ovarian cancer because elevated CA-125
levels can be found in individuals without ovarian cancer. For example, CA-125
is best known as a marker for ovarian cancer, endometrial cancer, breast
cancer, and gastrointestinal cancer. CA-125 may also be elevated in a number of
relatively benign conditions, such as endometriosis, several disease of the
ovary, menstruation, and a pregnancy.

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